2026.6.17
\n\u7814\u7a76\u8ab2\u984c
\n\u53cd\u5fa9\u6d41\u7523\uff08RPL\uff09\u3092\u7d4c\u9a13\u3059\u308b\u5973\u6027\u306e\u3046\u3061\u3001\u30d3\u30bf\u30df\u30f3D\u5024\u304c\u4f4e\u3044\u5973\u6027\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u5024\u304c\u6b63\u5e38\u306aRPL\u306e\u5973\u6027\u3068\u6bd4\u8f03\u3057\u3066\u3001\u81ea\u5df1\u514d\u75ab\u304a\u3088\u3073\u7d30\u80de\u6027\u514d\u75ab\u7570\u5e38\u306e\u6709\u75c5\u7387\u304c\u9ad8\u3044\u306e\u304b\u3002\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u4f53\u5916\u306b\u304a\u3051\u308b\u7d30\u80de\u6027\u514d\u75ab\u306b\u4f55\u3089\u304b\u306e\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u3002<\/p>\n
\u7fd2\u6163\u6027\u6d41\u7523\uff08RPL\uff09\u306e\u5973\u6027\u306e\u591a\u304f\u306f\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u3092\u5408\u4f75\u3057\u3066\u304a\u308a\u3001RPL\u3068\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u3092\u4f75\u767a\u3057\u3066\u3044\u308b\u5973\u6027\u3067\u306f\u3001\u81ea\u5df1\u514d\u75ab\u304a\u3088\u3073\u7d30\u80de\u6027\u514d\u75ab\u7570\u5e38\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n
\u598a\u5a66\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306f\u3001\u598a\u5a20\u9ad8\u8840\u5727\u75c7\u5019\u7fa4\u3001\u7d30\u83cc\u6027\u81a3\u708e\u306b\u4f34\u3046\u65e9\u7523\u3001\u598a\u5a20\u7cd6\u5c3f\u75c5\u3001\u5728\u80ce\u9031\u6570\u306b\u6bd4\u3079\u3066\u5c0f\u3055\u3044\u5150\u306e\u51fa\u7523\u306a\u3069\u3001\u7523\u79d1\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002<\/p>\n
2\u5e74\u9593\u306b\u308f\u305f\u3063\u3066\u767b\u9332\u3055\u308c\u305f\u7fd2\u6163\u6027\u6d41\u7523\uff08RPL\uff09\u306e\u5973\u6027133\u540d\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5f8c\u5411\u304d\u6a2a\u65ad\u7814\u7a76\u3068\u3001\u5b9f\u9a13\u5ba4\u3067\u306e\u5b9f\u9a13\u3092\u5b9f\u65bd\u3057\u305f<\/p>\n
\u5927\u5b66\u75c5\u9662\u3092\u53d7\u8a3a\u3057\u305f\u3001\u598a\u5a2020\u9031\u672a\u6e80\u30673\u56de\u4ee5\u4e0a\u9023\u7d9a\u3057\u3066\u81ea\u7136\u6d41\u7523\u3092\u7d4c\u9a13\u3057\u305f\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u8840\u6e05\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3001\u7d30\u80de\u6d3b\u6027\u3001\u304a\u3088\u3073\u751f\u4f53\u5185\u30fb\u751f\u4f53\u5916\u3067\u306e\u81ea\u5df1\u514d\u75ab\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3092\u6e2c\u5b9a\u3057\u305f\u3002<\/p>\n
\u4e3b\u306a\u7d50\u679c\u3068\u5076\u7136\u6027\u306e\u5f79\u5272<\/p>\n
<\/p>\n
133\u540d\u306e\u5973\u6027\u306e\u3046\u306163\u540d\uff0847.4%\uff09\u304c\u30d3\u30bf\u30df\u30f3D\u4f4e\u5024\uff0830 ng\/ml\u672a\u6e80\uff09\u3067\u3057\u305f\u3002\u6297\u30ea\u30f3\u8102\u8cea\u6297\u4f53\uff08APA\uff09\u306e\u967d\u6027\u7387\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u4f4e\u5024\u7fa4\uff08VDlow\uff09\uff0839.7%\uff09\u304c\u30d3\u30bf\u30df\u30f3D\u6b63\u5e38\u5024\u7fa4\uff08VDnl\uff09\uff0822.9%\uff09\u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u304f\uff08P<0.05\uff09\u3001VDlow\u306b\u304a\u3051\u308bAPA\u306e\u8abf\u6574\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u306f2.22\u300195%\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u306f1.0?4.7\u3067\u3057\u305f\u3002\u6297\u6838\u6297\u539f\u6297\u4f53\uff08VDlow \u5bfe VDnl; 23.8% \u5bfe 10.0%\u3001OR 2.81\u300195% CI 1.1?7.4\uff09\u3001\u6297ssDNA\u6297\u4f53\uff0819.0% \u5bfe 5.7%\u3001OR 3.76\u300195% CI 1.1?12.4\uff09\u3001\u304a\u3088\u3073\u30c1\u30ed\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u6297\u4f53\uff0833.3% \u5bfe 15.7%\u3001OR 2.68\u300195% CI 1.2?6.1\uff09\u306e\u6709\u75c5\u7387\u306f\u3001VDlow \u306e\u65b9\u304c VDnl \u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff08\u3044\u305a\u308c\u3082 P < 0.05\uff09\u3002\u672b\u68a2\u8840 CD19+ B \u7d30\u80de\u304a\u3088\u3073 CD56+ NK \u7d30\u80de\u306e\u30ec\u30d9\u30eb\u3001\u306a\u3089\u3073\u306b\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u5bfe\u6a19\u7684\u7d30\u80de\uff08E:T\uff09\u6bd4 25:1 \u3067\u306e NK \u7d30\u80de\u50b7\u5bb3\u6027\u306f\u3001VDlow \u306e\u65b9\u304c VDnl \u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff08\u3044\u305a\u308c\u3082 P < 0.05\uff09\u3002 IgG (12.5 mg\/dl) \u306b\u3088\u308b NK \u7d30\u80de\u50b7\u5bb3\u6027 (E:T \u6bd4 50:1 \u304a\u3088\u3073 25:1 \u306e\u5834\u5408) \u306e\u6e1b\u5c11\u7387 (%) \u306f\u3001VDlow \u3067\u306f VDnl \u3088\u308a\u3082\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f (\u305d\u308c\u305e\u308c P < 0.05\u3001P < 0.01)\u3002VDlow \u3068 VDnl \u306e\u9593\u306b Th1\/Th2 \u6bd4\u306e\u5dee\u306f\u306a\u304b\u3063\u305f\u3002in vitro \u306e NK \u7d30\u80de\u50b7\u5bb3\u6027\u30a2\u30c3\u30bb\u30a4\u306b\u30d3\u30bf\u30df\u30f3 D3 \u3092\u52a0\u3048\u305f\u5834\u5408\u3001E:T \u6bd4 50:1 \u3067\u306e NK \u7d30\u80de\u50b7\u5bb3\u6027\u306f\u3001\u5bfe\u7167\u7fa4 (15.3 \u00b1 4.7%) \u3068\u6bd4\u8f03\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3 D3 10 nMol\/L (nM) (11.9 \u00b1 3.3%) \u304a\u3088\u3073 100 nM (10.9 \u00b1 3.7%) \u3067\u6709\u610f\u306b\u6291\u5236\u3055\u308c\u305f (\u305d\u308c\u305e\u308c P < 0.01)\u3002 TNF-\u03b1\/IL-10\u3092\u767a\u73fe\u3059\u308bCD3+\/4+\u7d30\u80de\u6bd4\u306f\u3001100 nM\u306e\u30d3\u30bf\u30df\u30f3D3\u3067\u5bfe\u7167\u7fa4\uff0840.4 \u00b1 11.3\uff09\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\uff0831.3 \u00b1 9.4\u3001P < 0.05\uff09\u3002\u3055\u3089\u306b\u3001INF-\u03b3\/IL-10\u3092\u767a\u73fe\u3059\u308bCD3+\/4+\u7d30\u80de\u6bd4\u3082\u3001100 nM\u306e\u30d3\u30bf\u30df\u30f3D3\u3067\u5bfe\u7167\u7fa4\uff0814.8 \u00b1 4.6\uff09\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\uff0812.1 \u00b1 4.0\u3001P < 0.05\uff09\u3002NK\u7d30\u80de\u304b\u3089\u306eIFN-\u03b3\u304a\u3088\u3073TNF-\u03b1\u306e\u5206\u6ccc\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u6e1b\u5c11\u3057\uff08\u305d\u308c\u305e\u308cP < 0.01\uff09\u3001IL-10\u3001IL-1\u03b2\u3001\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\u304a\u3088\u3073\u9846\u7c92\u7403\u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b50\u306e\u30ec\u30d9\u30eb\u306f\u3001100 nM\u306e\u30d3\u30bf\u30df\u30f3D3\u3067\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\uff08\u305d\u308c\u305e\u308cP < 0.01\uff09\u3002\n\n\u9650\u754c\u3068\u6ce8\u610f\u70b9\n\n\u672c\u7814\u7a76\u306b\u304a\u3051\u308b\u7fd2\u6163\u6027\u6d41\u7523\uff08RPL\uff09\u5973\u6027\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306e\u6709\u75c5\u7387\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3057\u3066\u3044\u305f\u5973\u6027\u304c\u9664\u5916\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u7b2c\u4e00\u7a2e\u904e\u8aa4\u306e\u53ef\u80fd\u6027\u304c\u6b8b\u308b\u3002\n\n\u7814\u7a76\u7d50\u679c\u306e\u3088\u308a\u5e83\u7bc4\u306a\u610f\u7fa9\n\n\u7fd2\u6163\u6027\u6d41\u7523\uff08RPL\uff09\u306e\u5973\u6027\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u306e\u8a55\u4fa1\u304c\u63a8\u5968\u3055\u308c\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001RPL\u306e\u6cbb\u7642\u9078\u629e\u80a2\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u3055\u3089\u306b\u691c\u8a0e\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3002\n\n\u8a73\u3057\u304f\u306f\u3053\u3061\u3089\nhttps:\/\/academic.oup.com\/humrep\/article-abstract\/29\/2\/208\/625581?redirectedFrom=fulltext&login=false<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" 2026.6.17 \u7814\u7a76\u8ab2\u984c \u53cd\u5fa9\u6d41\u7523\uff08RPL\uff09\u3092\u7d4c\u9a13\u3059\u308b\u5973\u6027\u306e\u3046\u3061\u3001\u30d3\u30bf\u30df\u30f3D\u5024\u304c\u4f4e\u3044\u5973\u6027\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u5024\u304c\u6b63\u5e38\u306aRPL\u306e\u5973\u6027\u3068\u6bd4\u8f03\u3057\u3066\u3001\u81ea\u5df1\u514d\u75ab\u304a\u3088\u3073\u7d30\u80de\u6027\u514d\u75ab\u7570\u5e38\u306e\u6709\u75c5\u7387\u304c\u9ad8\u3044\u306e\u304b\u3002\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u4f53\u5916\u306b\u304a\u3051\u308b\u7d30 … “\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306f\u3001\u7d30\u80de\u6027\u514d\u75ab\u3068\u81ea\u5df1\u514d\u75ab\u3092\u4ea2\u9032\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u53cd\u5fa9\u6d41\u7523\u306e\u5371\u967a\u56e0\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[478],"_links":{"self":[{"href":"https:\/\/acupunctures.info\/index.php?rest_route=\/wp\/v2\/posts\/3594"}],"collection":[{"href":"https:\/\/acupunctures.info\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/acupunctures.info\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/acupunctures.info\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/acupunctures.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3594"}],"version-history":[{"count":0,"href":"https:\/\/acupunctures.info\/index.php?rest_route=\/wp\/v2\/posts\/3594\/revisions"}],"wp:attachment":[{"href":"https:\/\/acupunctures.info\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/acupunctures.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/acupunctures.info\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}